Insulin signaling is required for insulin’s direct and indirect action on hepatic glucose production

We and others have suggested that insulin predominantly acts indirectly to inhibit hepatic glucose production (HGP) via suppression of gluconeogenic precursors, FFAs, and glucagon. To test that hypothesis, we performed high-dose hyperinsulinemic-euglycemic clamps using [3-(3)H]-glucose in liver-spec...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Fisher, Simon J., Kahn, C. Ronald
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 2003
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC151923/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12588884/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI16426
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