Phosphorylation of the myosin IIA tailpiece regulates single myosin IIA molecule association with lytic granules to promote NK-cell cytotoxicity

Natural killer (NK) cells are innate immune lymphocytes that provide critical defense against virally infected and transformed cells. NK-cell cytotoxicity requires the formation of an F-actin rich immunologic synapse (IS), as well as the polarization of perforin-containing lytic granules to the IS a...

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Главные авторы: Sanborn, Keri B., Mace, Emily M., Rak, Gregory D., Difeo, Analisa, Martignetti, John A., Pecci, Alessandro, Bussel, James B., Favier, Rémi, Orange, Jordan S.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Hematology 2011
Предметы:
Immunobiology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3228501/
https://ncbi.nlm.nih.gov/pubmed/22123909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-03-344846
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