Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cerevisiae

The Orm family proteins are conserved integral membrane proteins of the endoplasmic reticulum that are key homeostatic regulators of sphingolipid biosynthesis. Orm proteins bind to and inhibit serine:palmitoyl-coenzyme A transferase, the first enzyme in sphingolipid biosynthesis. In Saccharomyces ce...

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Main Authors: Roelants, Françoise M., Breslow, David K., Muir, Alexander, Weissman, Jonathan S., Thorner, Jeremy
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2011
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3228448/
https://ncbi.nlm.nih.gov/pubmed/22080611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1116948108
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