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Orm family proteins mediate sphingolipid homeostasis

Despite the essential roles of sphingolipids as both structural components of membranes and critical signalling molecules, we have a limited understanding of how cells sense and regulate their levels. Here we reveal the function in sphingolipid metabolism of the ORM/ORMDL genes, a conserved gene fam...

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Bibliographic Details
Main Authors: Breslow, David K., Collins, Sean R., Bodenmiller, Bernd, Aebersold, Ruedi, Simons, Kai, Shevchenko, Andrej, Ejsing, Christer S., Weissman, Jonathan S.
Format: Artigo
Language:Inglês
Published: 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2877384/
https://ncbi.nlm.nih.gov/pubmed/20182505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08787
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