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TORC2-dependent protein kinase Ypk1 phosphorylates ceramide synthase to stimulate synthesis of complex sphingolipids

Plasma membrane lipid composition must be maintained during growth and under environmental insult. In yeast, signaling mediated by TOR Complex 2 (TORC2)-dependent protein kinase Ypk1 controls lipid abundance and distribution in response to membrane stress. Ypk1, among other actions, alleviates negat...

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Bibliographische Detailangaben
Hauptverfasser: Muir, Alexander, Ramachandran, Subramaniam, Roelants, Françoise M, Timmons, Garrett, Thorner, Jeremy
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4217029/
https://ncbi.nlm.nih.gov/pubmed/25279700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.03779
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