Incorporation of 3-Aminobenzanthrone into 2′-Deoxyoligonucleotides and Its Impact on Duplex Stability

3-Nitrobenzanthrone (3NBA), an environmental pollutant and potent mutagen, causes DNA damage via the reaction of its metabolically activated form with the exocyclic amino groups of purines and the C-8 position of guanine. The present work describes a synthetic approach to the preparation of oligomer...

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Main Authors: Lukin, Mark, Zaliznyak, Tanya, Johnson, Francis, de los Santos, Carlos R.
Formato: Artigo
Idioma:Inglês
Publicado: SAGE-Hindawi Access to Research 2011
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3228337/
https://ncbi.nlm.nih.gov/pubmed/22175001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4061/2011/521035
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