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Concise route to defined stereoisomers of the hydroxy acid of the chondramides

The use of Kobayashi vinylogous aldol reaction in the reaction with acetaldehyde led to anti-aldol product 11. After reductive removal of the chiral auxiliary, the primary alcohol was converted to the allyliodide 14. This compound could be engaged in an Evans alkylation reaction, leading eventually...

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Autori principali: Schmauder, Anke, Müller, Sven, Maier, Martin E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3228260/
https://ncbi.nlm.nih.gov/pubmed/22140278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tet.2008.04.109
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