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Concise and Straightforward Asymmetric Synthesis of a Cyclic Natural Hydroxy-Amino Acid

An enantioselective total synthesis of the natural amino acid (2S,4R,5R)-4,5-di-hydroxy-pipecolic acid starting from D-glucoheptono-1, 4-lactone is presented. The best sequence employed as a key step the intramolecular nucleophilic displacement by an amino function of a 6-O-p-toluene-sulphonyl deriv...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Simirgiotis, Mario J., Vallejos, Javier, Areche, Carlos, Sepúlveda, Beatriz
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6271146/
https://ncbi.nlm.nih.gov/pubmed/25432006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules191219516
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