Part 2: Pharmacogenetic Variability in Drug Transport and Phase I Anticancer Drug Metabolism

Equivalent drug doses in anticancer chemotherapy may lead to wide interpatient variability in drug response reflected by differences in treatment response or in severity of adverse drug reactions. Differences in the pharmacokinetic (PK) and pharmacodynamic (PD) behavior of a drug contribute to varia...

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Autors principals: Deenen, Maarten J., Cats, Annemieke, Beijnen, Jos H., Schellens, Jan H.M.
Format: Artigo
Idioma:Inglês
Publicat: AlphaMed Press 2011
Matèries:
Clinical Pharmacology: Pharmacogenetics: Opportunities for Patient-Tailored Anticancer Therapy
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3228220/
https://ncbi.nlm.nih.gov/pubmed/21632461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2010-0259
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