Part 2: Pharmacogenetic Variability in Drug Transport and Phase I Anticancer Drug Metabolism

Equivalent drug doses in anticancer chemotherapy may lead to wide interpatient variability in drug response reflected by differences in treatment response or in severity of adverse drug reactions. Differences in the pharmacokinetic (PK) and pharmacodynamic (PD) behavior of a drug contribute to varia...

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Autori principali: Deenen, Maarten J., Cats, Annemieke, Beijnen, Jos H., Schellens, Jan H.M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: AlphaMed Press 2011
Soggetti:
Clinical Pharmacology: Pharmacogenetics: Opportunities for Patient-Tailored Anticancer Therapy
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3228220/
https://ncbi.nlm.nih.gov/pubmed/21632461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2010-0259
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