Part 2: Pharmacogenetic Variability in Drug Transport and Phase I Anticancer Drug Metabolism

Equivalent drug doses in anticancer chemotherapy may lead to wide interpatient variability in drug response reflected by differences in treatment response or in severity of adverse drug reactions. Differences in the pharmacokinetic (PK) and pharmacodynamic (PD) behavior of a drug contribute to varia...

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Détails bibliographiques
Auteurs principaux: Deenen, Maarten J., Cats, Annemieke, Beijnen, Jos H., Schellens, Jan H.M.
Format: Artigo
Langue:Inglês
Publié: AlphaMed Press 2011
Sujets:
Clinical Pharmacology: Pharmacogenetics: Opportunities for Patient-Tailored Anticancer Therapy
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3228220/
https://ncbi.nlm.nih.gov/pubmed/21632461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2010-0259
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