Part 2: Pharmacogenetic Variability in Drug Transport and Phase I Anticancer Drug Metabolism

Equivalent drug doses in anticancer chemotherapy may lead to wide interpatient variability in drug response reflected by differences in treatment response or in severity of adverse drug reactions. Differences in the pharmacokinetic (PK) and pharmacodynamic (PD) behavior of a drug contribute to varia...

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Bibliographic Details
Main Authors: Deenen, Maarten J., Cats, Annemieke, Beijnen, Jos H., Schellens, Jan H.M.
Format: Artigo
Language:Inglês
Published: AlphaMed Press 2011
Subjects:
Clinical Pharmacology: Pharmacogenetics: Opportunities for Patient-Tailored Anticancer Therapy
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3228220/
https://ncbi.nlm.nih.gov/pubmed/21632461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2010-0259
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