Measuring Tumor Aggressiveness and Targeting Metastatic Lesions with Fluorescent pHLIP

PURPOSE: Malignant cancer foci develop acidic extracellular environments. Mild acidic conditions trigger insertion and folding of the pH (low) insertion peptide (pHLIP(™)) across a cellular membrane, enabling targeting of such lesions. PROCEDURES: We employed optical imaging to follow targeting by f...

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Bibliographic Details
Main Authors: Reshetnyak, Yana K., Yao, Lan, Zheng, Sida, Kuznetsov, Sergey, Engelman, Donald M., Andreev, Oleg A.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3227673/
https://ncbi.nlm.nih.gov/pubmed/21181501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11307-010-0457-z
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