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Targeting Acetylcholinesterase: Identification of Chemical Leads by High Throughput Screening, Structure Determination and Molecular Modeling

Acetylcholinesterase (AChE) is an essential enzyme that terminates cholinergic transmission by rapid hydrolysis of the neurotransmitter acetylcholine. Compounds inhibiting this enzyme can be used (inter alia) to treat cholinergic deficiencies (e.g. in Alzheimer's disease), but may also act as d...

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Bibliographic Details
Main Authors: Berg, Lotta, Andersson, C. David, Artursson, Elisabet, Hörnberg, Andreas, Tunemalm, Anna-Karin, Linusson, Anna, Ekström, Fredrik
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3227566/
https://ncbi.nlm.nih.gov/pubmed/22140425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0026039
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