Structure of a prereaction complex between the nerve agent sarin, its biological target acetylcholinesterase, and the antidote HI-6

Organophosphorus nerve agents interfere with cholinergic signaling by covalently binding to the active site of the enzyme acetylcholinesterase (AChE). This inhibition causes an accumulation of the neurotransmitter acetylcholine, potentially leading to overstimulation of the nervous system and death....

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Bibliographische Detailangaben
Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Allgardsson, Anders, Berg, Lotta, Akfur, Christine, Hörnberg, Andreas, Worek, Franz, Linusson, Anna, Ekström, Fredrik J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2016
Schlagworte:
Physical Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4878515/
https://ncbi.nlm.nih.gov/pubmed/27140636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1523362113
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