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Structure of a prereaction complex between the nerve agent sarin, its biological target acetylcholinesterase, and the antidote HI-6

Organophosphorus nerve agents interfere with cholinergic signaling by covalently binding to the active site of the enzyme acetylcholinesterase (AChE). This inhibition causes an accumulation of the neurotransmitter acetylcholine, potentially leading to overstimulation of the nervous system and death....

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Allgardsson, Anders, Berg, Lotta, Akfur, Christine, Hörnberg, Andreas, Worek, Franz, Linusson, Anna, Ekström, Fredrik J.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4878515/
https://ncbi.nlm.nih.gov/pubmed/27140636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1523362113
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