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Targeting Acetylcholinesterase: Identification of Chemical Leads by High Throughput Screening, Structure Determination and Molecular Modeling

Acetylcholinesterase (AChE) is an essential enzyme that terminates cholinergic transmission by rapid hydrolysis of the neurotransmitter acetylcholine. Compounds inhibiting this enzyme can be used (inter alia) to treat cholinergic deficiencies (e.g. in Alzheimer's disease), but may also act as d...

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Detalhes bibliográficos
Main Authors: Berg, Lotta, Andersson, C. David, Artursson, Elisabet, Hörnberg, Andreas, Tunemalm, Anna-Karin, Linusson, Anna, Ekström, Fredrik
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3227566/
https://ncbi.nlm.nih.gov/pubmed/22140425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0026039
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