Deep-transcriptome and ribonome sequencing redefines the molecular networks of pluripotency and the extracellular space in human embryonic stem cells

Recent RNA-sequencing studies have shown remarkable complexity in the mammalian transcriptome. The ultimate impact of this complexity on the predicted proteomic output is less well defined. We have undertaken strand-specific RNA sequencing of multiple cellular RNA fractions (>20 Gb) to uncover th...

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Autores principales: Kolle, Gabriel, Shepherd, Jill L., Gardiner, Brooke, Kassahn, Karin S., Cloonan, Nicole, Wood, David L.A., Nourbakhsh, Ehsan, Taylor, Darrin F., Wani, Shivangi, Chy, Hun S., Zhou, Qi, McKernan, Kevin, Kuersten, Scott, Laslett, Andrew L., Grimmond, Sean M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2011
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3227092/
https://ncbi.nlm.nih.gov/pubmed/22042643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.119321.110
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