Imperfect centered miRNA binding sites are common and can mediate repression of target mRNAs

BACKGROUND: MicroRNAs (miRNAs) bind to mRNAs and target them for translational inhibition or transcriptional degradation. It is thought that most miRNA-mRNA interactions involve the seed region at the 5′ end of the miRNA. The importance of seed sites is supported by experimental evidence, although t...

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Detalhes bibliográficos
Main Authors: Martin, Hilary C, Wani, Shivangi, Steptoe, Anita L, Krishnan, Keerthana, Nones, Katia, Nourbakhsh, Ehsan, Vlassov, Alexander, Grimmond, Sean M, Cloonan, Nicole
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4053950/
https://ncbi.nlm.nih.gov/pubmed/24629056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2014-15-3-r51
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