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Mg(2+) binding to open and closed states can activate BK channels provided that the voltage sensors are elevated

BK channels are activated by intracellular Ca(2+) and Mg(2+) as well as by depolarization. Such activation is possible because each of the four subunits has two high-affinity Ca(2+) sites, one low-affinity Mg(2+) site, and a voltage sensor. This study further investigates the mechanism of Mg(2+) act...

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Detalhes bibliográficos
Main Authors: Chen, Ren-Shiang, Geng, Yanyan, Magleby, Karl L.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3226971/
https://ncbi.nlm.nih.gov/pubmed/22124117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201110707
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