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NMR Studies Reveal an Unexpected Binding Site for a Redox Inhibitor of AP Endonuclease 1
AP endonuclease 1 (APE1) is a multi-faceted protein with essential roles in DNA repair and transcriptional regulation. APE1 (Ref-1) activates many transcription factors (TF), including AP-1 and NF-κB. While the mechanism of APE1 redox activity remains unknown, it may involve reduction of an oxidized...
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2011
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3226889/ https://ncbi.nlm.nih.gov/pubmed/22032234 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201071g |
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