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Discovery, Synthesis, SAR Development of a Series of N-4-(2,5-dioxopyrrolidin-1-yl)-phenylpicolinamides (VU0400195, ML182): Characterization of a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu(4)) with Oral Efficacy in an anti-Parkinsonian Animal Model

There is an increasing amount of literature data showing the positive effects on preclinical anti-Parkinsonian rodent models with selective positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu(4)). However, most of the data generated utilize compounds that have not been optimize...

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書誌詳細
主要な著者: Jones, Carrie K., Engers, Darren W., Thompson, Analisa D., Field, Julie R., Blobaum, Anna L., Lindsley, Stacey R., Zhou, Ya, Gogliotti, Rocco D., Jadhav, Satyawan, Zamorano, Rocio, Bogenpohl, Jim, Smith, Yoland, Morrison, Ryan, Daniels, J. Scott, Weaver, C. David, Conn, P. Jeffrey, Lindsley, Craig W., Niswender, Colleen M., Hopkins, Corey R.
フォーマット: Artigo
言語:Inglês
出版事項: 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3226828/
https://ncbi.nlm.nih.gov/pubmed/21966889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm200956q
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