Compartmental Modeling of (11)C-HOMADAM Binding to the Serotonin Transporter in the Healthy Human Brain

The novel PET radioligand (11)C-N,N-dimethyl-2-(2′-amino-4′-hydroxymethylphenylthio)benzylamine ((11)C-HOMADAM) binds with high affinity and selectively to the serotonin transporter (SERT). The purpose of this study was to develop a reliable kinetic model to describe the uptake of (11)C-HOMADAM in t...

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Detalhes bibliográficos
Main Authors: Nye, Jonathon A., Votaw, John R., Jarkas, Nachwa, Purselle, David, Camp, Vernon, Bremner, James D., Kilts, Clinton D., Nemeroff, Charles B., Goodman, Mark M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3226704/
https://ncbi.nlm.nih.gov/pubmed/19038997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.108.054262
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