Synthesis, Radiosynthesis, and Biological Evaluation of Carbon-11 and Fluorine-18 Labeled Reboxetine Analogs: Potential Positron Emission Tomography Radioligands for in Vivo Imaging of the Norepinephrine Transporter

Reboxetine analogs with methyl and fluoroalkyl substituents at position 2 of the phenoxy ring 1–4 were synthesized. In vitro competition binding demonstrated that 1–4 have a high affinity for the norepinephrine transporter (NET) with K(i)’s = 1.02, 3.14, 3.68, and 0.30 nM (vs [(3)H]nisoxetine), resp...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Zeng, Fanxing, Mun, Jiyoung, Jarkas, Nachwa, Stehouwer, Jeffrey S., Voll, Ronald J., Tamagnan, Gilles D., Howell, Leonard, Votaw, John R., Kilts, Clinton D., Nemeroff, Charles B., Goodman, Mark M.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2009
נושאים:
Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2746395/
https://ncbi.nlm.nih.gov/pubmed/19067522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800817h
תגים: הוספת תג
אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!

פריטים דומים