Synthesis, Radiosynthesis, and Biological Evaluation of Fluorine-18 Labeled 2β-Carbo(fluoroalkoxy)-3β-(3′-((Z)-2-haloethenyl)phenyl)nortropanes: Candidate Radioligands for In Vivo Imaging of the Serotonin Transporter with Positron Emission Tomography

The meta-vinylhalide fluoroalkyl ester nortropanes 1-4 were synthesized as ligands of the serotonin transporter (SERT) for use as positron emission tomography (PET) imaging agents. In vitro competition binding assays demonstrated that 1-4 have a high affinity for the SERT (K(i)'s = 0.3 - 0.4 nM...

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Main Authors: Stehouwer, Jeffrey S., Jarkas, Nachwa, Zeng, Fanxing, Voll, Ronald J., Williams, Larry, Camp, Vernon M., Malveaux, Eugene J., Votaw, John R., Howell, Leonard, J.Owens, Michael, Goodman, Mark M.
Format: Artigo
Jezik:Inglês
Izdano: 2008
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2668213/
https://ncbi.nlm.nih.gov/pubmed/19053782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800781a
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