Synthesis, Radiosynthesis, and Biological Evaluation of Fluorine-18 Labeled 2β-Carbo(fluoroalkoxy)-3β-(3′-((Z)-2-haloethenyl)phenyl)nortropanes: Candidate Radioligands for In Vivo Imaging of the Serotonin Transporter with Positron Emission Tomography

The meta-vinylhalide fluoroalkyl ester nortropanes 1-4 were synthesized as ligands of the serotonin transporter (SERT) for use as positron emission tomography (PET) imaging agents. In vitro competition binding assays demonstrated that 1-4 have a high affinity for the SERT (K(i)'s = 0.3 - 0.4 nM...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Stehouwer, Jeffrey S., Jarkas, Nachwa, Zeng, Fanxing, Voll, Ronald J., Williams, Larry, Camp, Vernon M., Malveaux, Eugene J., Votaw, John R., Howell, Leonard, J.Owens, Michael, Goodman, Mark M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2668213/
https://ncbi.nlm.nih.gov/pubmed/19053782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800781a
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky