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Evolutionary development of redundant nuclear localization signals in the mRNA export factor NXF1

In human cells, the mRNA export factor NXF1 resides in the nucleoplasm and at nuclear pore complexes. Karyopherin β2 or transportin recognizes a proline–tyrosine nuclear localization signal (PY-NLS) in the N-terminal tail of NXF1 and imports it into the nucleus. Here biochemical and cellular studies...

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Hlavní autoři: Zhang, Zi Chao, Satterly, Neal, Fontoura, Beatriz M. A., Chook, Yuh Min
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Cell Biology 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3226482/
https://ncbi.nlm.nih.gov/pubmed/21965294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E11-03-0222
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