T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice

Many autoimmune diseases exhibit familial aggregation, indicating that they have genetic determinants. Single nucleotide polymorphisms in PTPN2, which encodes T cell protein tyrosine phosphatase (TCPTP), have been linked with the development of several autoimmune diseases, including type 1 diabetes...

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Main Authors: Wiede, Florian, Shields, Benjamin J., Chew, Sock Hui, Kyparissoudis, Konstantinos, van Vliet, Catherine, Galic, Sandra, Tremblay, Michel L., Russell, Sarah M., Godfrey, Dale I., Tiganis, Tony
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3226006/
https://ncbi.nlm.nih.gov/pubmed/22080863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI59492
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