Strain-Dependent Differences in Bone Development, Myeloid Hyperplasia, Morbidity and Mortality in Ptpn2-Deficient Mice

Single nucleotide polymorphisms in the gene encoding the protein tyrosine phosphatase TCPTP (encoded by PTPN2) have been linked with the development of autoimmunity. Here we have used Cre/LoxP recombination to generate Ptpn2(ex2−/ex2−) mice with a global deficiency in TCPTP on a C57BL/6 background a...

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Main Authors: Wiede, Florian, Chew, Sock Hui, van Vliet, Catherine, Poulton, Ingrid J., Kyparissoudis, Konstantinos, Sasmono, Tedjo, Loh, Kim, Tremblay, Michel L., Godfrey, Dale I., Sims, Natalie A., Tiganis, Tony
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3348136/
https://ncbi.nlm.nih.gov/pubmed/22590589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036703
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