Carregant...

The improvement of an anti-CD22 immunotoxin: Conversion to single-chain and disulfide stabilized form and affinity maturation by alanine scan

HA22-LR is a recombinant immunotoxin for the treatment of B-cell malignancies that contains the Fv portion of an anti-CD22 antibody fused to a functional portion of Pseudomonas exotoxin A. In the present study, we attempted to improve this molecule. First, we produced a single-chain version of HA22-...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Kawa, Seiji, Onda, Masanori, Ho, Mitchell, Kreitman, Robert J, Bera, Tapan K, Pastan, Ira
Format: Artigo
Idioma:Inglês
Publicat: Landes Bioscience 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3225852/
https://ncbi.nlm.nih.gov/pubmed/22048691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.3.5.17228
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!