A flow cytometry method to quantitate internalized immunotoxin shows Taxol synergistically increases cellular immunotoxin uptake

Cancer cells within solid tumors live in a unique microenvironment containing barriers impairing the penetration of antibodies, immunoconjugates and immunotoxins. SS1P is an immunotoxin composed of the Fv portion of a mesothelinspecific antibody fused to a bacterial toxin and is now undergoing Phase...

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Main Authors: Zhang, Yujian, Hansen, Johanna, Xiang, Laiman, Kawa, Seiji, Onda, Masanori, Ho, Mitchell, Hassan, Raffit, Pastan, Ira
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818704/
https://ncbi.nlm.nih.gov/pubmed/20103626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-2405
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