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Immunotoxin and Taxol synergy results from a decrease in shed mesothelin levels in the extracellular space of tumors

Recombinant immunotoxins are chimeric proteins composed of the Fv portion of a tumor-specific antibody fused to a toxin. SS1P (CAT-5001) is an immunotoxin composed of an antimesothelin Fv fused to a 38-kDa portion of Pseudomonas exotoxin A. Immunotoxins have been shown to be active in lymphomas and...

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Sonraí Bibleagrafaíochta
Main Authors: Zhang, Yujian, Xiang, Laiman, Hassan, Raffit, Pastan, Ira
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2007
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2040446/
https://ncbi.nlm.nih.gov/pubmed/17940013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0708101104
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