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Striatal Neuroprotection from Neonatal Hypoxia-Ischemia in Piglets by Antioxidant Treatment with EUK-134 or Edaravone

Striatal neurons are highly vulnerable to hypoxia-ischemia (HI) in term newborns. In a piglet model of HI, striatal neurons develop oxidative stress and organelle disruption by 3–6 h of recovery and ischemic cytopathology over 6–24 h of recovery. We tested the hypothesis that early treatment with th...

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Detalhes bibliográficos
Main Authors: Ni, Xinli, Yang, Zeng-Jin, Carter, Erin L., Martin, Lee J., Koehler, Raymond C.
Formato: Artigo
Idioma:Inglês
Publicado em: S. Karger AG 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3225250/
https://ncbi.nlm.nih.gov/pubmed/21701140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000327243
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