Inhibitory Activity of Ferroquine, versus Chloroquine, against Western Kenya Plasmodium falciparum Field Isolates Determined by a SYBR Green I In Vitro Assay

Ferroquine (FQ), a chloroquine (CQ) analog, is being developed to treat persons with Plasmodium falciparum malaria. In 146 P. falciparum field isolates from western Kenya, we measured 50% inhibitory concentrations (IC(50); nM) of CQ and FQ by a SYBR Green I in vitro assay. Reference clones included...

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Autores principales: Eyase, Fredrick L., Akala, Hoseah M., Johnson, Jacob D., Walsh, Douglas S.
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society of Tropical Medicine and Hygiene 2011
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3225175/
https://ncbi.nlm.nih.gov/pubmed/22144431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4269/ajtmh.2011.11-0260
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