Polymorphisms in Pfmdr1, Pfcrt, and Pfnhe1 Genes Are Associated with Reduced In Vitro Activities of Quinine in Plasmodium falciparum Isolates from Western Kenya

In combination with antibiotics, quinine is recommended as the second-line treatment for uncomplicated malaria, an alternative first-line treatment for severe malaria, and for treatment of malaria in the first trimester of pregnancy. Quinine has been shown to have frequent clinical failures, and yet...

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Autors principals: Cheruiyot, Jelagat, Ingasia, Luicer A., Omondi, Angela A., Juma, Dennis W., Opot, Benjamin H., Ndegwa, Joseph M., Mativo, Joan, Cheruiyot, Agnes C., Yeda, Redemptah, Okudo, Charles, Muiruri, Peninah, Bidii, Ngalah S., Chebon, Lorna J., Angienda, Paul O., Eyase, Fredrick L., Johnson, Jacob D., Bulimo, Wallace D., Andagalu, Ben, Akala, Hoseah M., Kamau, Edwin
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2014
Matèries:
Epidemiology and Surveillance
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4068580/
https://ncbi.nlm.nih.gov/pubmed/24752268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02472-14
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