Genetic deletion of monoacylglycerol lipase alters endocannabinoid-mediated retrograde synaptic depression in the cerebellum

ABSTRACT: The endocannabinoid (eCB) 2-arachidonoylglycerol (2-AG) is hydrolysed primarily by monoacylglycerol lipase (MAGL). Here, we investigated whether eCB-mediated retrograde synaptic depression in cerebellar slices was altered in MAGL knockout (MAGL(−/−)) mice. Depolarization-induced suppressio...

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Hlavní autoři: Zhong, Peng, Pan, Bin, Gao, Xiu-ping, Blankman, Jacqueline L, Cravatt, Benjamin F, Liu, Qing-song
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2011
Témata:
Neuroscience: Cellular/Molecular
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3224879/
https://ncbi.nlm.nih.gov/pubmed/21911610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2011.215509
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