Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis

Plasma HDL levels have a protective role in atherosclerosis, yet clinical therapies to raise HDL levels have remained elusive. Recent advances in the understanding of lipid metabolism have revealed that miR-33, an intronic microRNA located within the SREBF2 gene, suppresses expression of the cholest...

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Detalhes bibliográficos
Main Authors: Rayner, Katey J., Sheedy, Frederick J., Esau, Christine C., Hussain, Farah N., Temel, Ryan E., Parathath, Saj, van Gils, Janine M., Rayner, Alistair J., Chang, Aaron N., Suarez, Yajaira, Fernandez-Hernando, Carlos, Fisher, Edward A., Moore, Kathryn J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3223840/
https://ncbi.nlm.nih.gov/pubmed/21646721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI57275
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