Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin αvβ8–mediated activation of TGF-β

The airway is a primary portal of entry for noxious environmental stimuli that can trigger airway remodeling, which contributes significantly to airway obstruction in chronic obstructive pulmonary disease (COPD) and chronic asthma. Important pathologic components of airway remodeling include fibrosi...

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Main Authors: Kitamura, Hideya, Cambier, Stephanie, Somanath, Sangeeta, Barker, Tyren, Minagawa, Shunsuke, Markovics, Jennifer, Goodsell, Amanda, Publicover, Jean, Reichardt, Louis, Jablons, David, Wolters, Paul, Hill, Arthur, Marks, James D., Lou, Jianlong, Pittet, Jean-Francois, Gauldie, Jack, Baron, Jody Lynn, Nishimura, Stephen L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3223836/
https://ncbi.nlm.nih.gov/pubmed/21646718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI45589
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