Interleukin-1β Induces Increased Transcriptional Activation of the Transforming Growth Factor-β-activating Integrin Subunit β8 through Altering Chromatin Architecture

The integrin αvβ8 is a cell surface receptor for the latent domain (LAP) of the multifunctional cytokine TGF-β. Through its association with LAP, TGF-β is maintained in a latent form that must be activated to function. Binding to the integrin αvβ8 with subsequent metalloproteolytic cleavage of LAP r...

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Detalhes bibliográficos
Main Authors: Markovics, Jennifer A., Araya, Jun, Cambier, Stephanie, Somanath, Sangeeta, Gline, Stephanie, Jablons, David, Hill, Arthur, Wolters, Paul J., Nishimura, Stephen L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Gene Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196125/
https://ncbi.nlm.nih.gov/pubmed/21878622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.276790
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