DNA-PK Mediates AKT Activation and Apoptosis Inhibition in Clinically Acquired Platinum Resistance

Clinical resistance to chemotherapy is a frequent event in cancer treatment and is closely linked to poor outcome. High-grade serous (HGS) ovarian cancer is characterized by p53 mutation and high levels of genomic instability. Treatment includes platinum-based chemotherapy and initial response rates...

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Main Authors: Stronach, Euan A, Chen, Michelle, Maginn, Elaina N, Agarwal, Roshan, Mills, Gordon B, Wasan, Harpreet, Gabra, Hani
Format: Artigo
Sprog:Inglês
Udgivet: Neoplasia Press Inc. 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3223610/
https://ncbi.nlm.nih.gov/pubmed/22131882
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