Combined inhibition of the PI3K/mTOR/MEK pathway induces Bim/Mcl-1-regulated apoptosis in pancreatic cancer cells

Pancreatic ductal adenocarcinoma (PDAC) progression and chemotherapy insensitivity have been associated with aberrant PI3K/mTOR/MEK signalling. However, cell death responses activated by inhibitors of these pathways can differ – contextually varying with tumour genetic background. Here, we demonstra...

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Bibliografiske detaljer
Udgivet i:Cancer Biol Ther
Main Authors: Burmi, Rajpal S., Maginn, Elaina N., Gabra, Hani, Stronach, Euan A., Wasan, Harpreet S.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2018
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6343713/
https://ncbi.nlm.nih.gov/pubmed/30261145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2018.1504718
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