HIF-1-dependent Expression of Angiopoietin-like 4 and L1CAM Mediates Vascular Metastasis of Hypoxic Breast Cancer Cells to the Lungs

Most cases of breast cancer mortality are due to vascular metastasis. Breast cancer cells must intravasate through endothelial cells (ECs) to enter a blood vessel in the primary tumor and then adhere to ECs and extravasate at the metastatic site. In this study we demonstrate that inhibition of hypox...

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Detalhes bibliográficos
Main Authors: Zhang, H, Wong, CCL, Wei, H, Gilkes, DM, Korangath, P, Chaturvedi, P, Schito, L, Chen, J, Krishnamachary, B, Winnard, PT, Raman, V, Zhen, L, Mitzner, WA, Sukumar, S, Semenza, GL
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3223555/
https://ncbi.nlm.nih.gov/pubmed/21860410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.365
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