Mitochondrial aging is accelerated by anti-retroviral therapy through the clonal expansion of mtDNA mutations

There is emerging evidence that people with successfully treated HIV infection age prematurely leading to progressive multi-organ disease (1), but the reasons for this are not known. Here we show that patients treated with commonly used nucleoside analog anti-retroviral drugs (NRTIs) progressively a...

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Hlavní autoři: Payne, Brendan A I, Wilson, Ian J, Hateley, Charlotte A, Horvath, Rita, Santibanez-Koref, Mauro, Samuels, David C, Price, D Ashley, Chinnery, Patrick F
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3223397/
https://ncbi.nlm.nih.gov/pubmed/21706004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.863
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