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Clonal expansion of mtDNA deletions: different disease models assessed by digital droplet PCR in single muscle cells
Deletions in mitochondrial DNA (mtDNA) are an important cause of human disease and their accumulation has been implicated in the ageing process. As mtDNA is a high copy number genome, the coexistence of deleted and wild-type mtDNA molecules within a single cell defines heteroplasmy. When deleted mtD...
Shranjeno v:
| izdano v: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group UK
2018
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6076247/ https://ncbi.nlm.nih.gov/pubmed/30076399 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-30143-z |
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