Clonal expansion of mtDNA deletions: different disease models assessed by digital droplet PCR in single muscle cells

Deletions in mitochondrial DNA (mtDNA) are an important cause of human disease and their accumulation has been implicated in the ageing process. As mtDNA is a high copy number genome, the coexistence of deleted and wild-type mtDNA molecules within a single cell defines heteroplasmy. When deleted mtD...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Trifunov, Selena, Pyle, Angela, Valentino, Maria Lucia, Liguori, Rocco, Yu-Wai-Man, Patrick, Burté, Florence, Duff , Jennifer, Kleinle, Stephanie, Diebold, Isabel, Rugolo, Michela, Horvath, Rita, Carelli, Valerio
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6076247/
https://ncbi.nlm.nih.gov/pubmed/30076399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-30143-z
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