Does Reduced IGF-1R Signaling in Igf1r (+/−) Mice Alter Aging?

Mutations in insulin/IGF-1 signaling pathway have been shown to lead to increased longevity in various invertebrate models. Therefore, the effect of the haplo- insufficiency of the IGF-1 receptor (Igf1r(+/−)) on longevity/aging was evaluated in C57Bl/6 mice using rigorous criteria where lifespan and...

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Main Authors: Bokov, Alex F., Garg, Neha, Ikeno, Yuji, Thakur, Sachin, Musi, Nicolas, DeFronzo, Ralph A., Zhang, Ning, Erickson, Rebecca C., Gelfond, Jon, Hubbard, Gene B., Adamo, Martin L., Richardson, Arlan
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2011
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3223158/
https://ncbi.nlm.nih.gov/pubmed/22132081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0026891
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