Reductions in serum IGF-1 during aging impair health span

In lower or simple species, such as worms and flies, disruption of the insulin-like growth factor (IGF)-1 and the insulin signaling pathways has been shown to increase lifespan. In rodents, however, growth hormone (GH) regulates IGF-1 levels in serum and tissues and can modulate lifespan via/or inde...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Gong, Zhenwei, Kennedy, Oran, Sun, Hui, Wu, YingJie, Williams, Garry A, Klein, Laura, Cardoso, Luis, Matheny, Ronald W, Hubbard, Gene B, Ikeno, Yuji, Farrar, Roger P, Schaffler, Mitchell B, Adamo, Martin L, Muzumdar, Radhika H, Yakar, Shoshana
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326899/
https://ncbi.nlm.nih.gov/pubmed/24341939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12188
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