RASSF1A and the BH3-only mimetic ABT-737 promote apoptosis in pediatric medulloblastoma cell lines

The RASSF1A tumor suppressor is potentially the most important candidate gene identified in medulloblastoma to date, being epigenetically silenced in >79% of primary tumors. However, its functional role has not been previously addressed in this tumor type. Here, we demonstrate that expression of...

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Hlavní autoři: Levesley, Jane, Lusher, Meryl E., Lindsey, Janet C., Clifford, Steven C., Grundy, Richard, Coyle, Beth
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2011
Témata:
Basic and Translational Investigations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3223089/
https://ncbi.nlm.nih.gov/pubmed/21880625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nor129
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