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Manipulating substrate and pH in zymogr aphy protocols selectively distinguishes cathepsins K, L, S, and V activity in cells and tissues

Cathepsins K, L, S, and V are cysteine proteases that have been implicated in tissue-destructive diseases such as atherosclerosis, tumor metastasis, and osteoporosis. Among these four cathepsins are the most powerful human collagenases and elastases, and they share 60% sequence homology. Proper quan...

詳細記述

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書誌詳細
主要な著者: Wilder, Catera L., Park, Keon-Young, Keegan, Philip M., Platt, Manu O.
フォーマット: Artigo
言語:Inglês
出版事項: 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3221864/
https://ncbi.nlm.nih.gov/pubmed/21982919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2011.09.009
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