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c-Myb and GATA-3 cooperatively regulate IL-13 expression via CGRE and recruit MLL for histone modification of the IL-13 locus

The c-Myb and GATA-3 transcription factors play important roles in T-cell development. We recently reported that c-Myb, GATA-3, and Menin form a core transcription complex that regulates GATA-3 expression and ultimately Th2 cell development in human peripheral blood T-cells. However, c-Myb roles for...

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Detalhes bibliográficos
Main Authors: Kozuka, Teruhiko, Sugita, Mayumi, Shetzline, Susan, Gewirtz, Alan M, Nakata, Yuji
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3221810/
https://ncbi.nlm.nih.gov/pubmed/22039304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1100550
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