A unified model of mammalian BCL-2 protein family interactions at the mitochondria

During apoptosis, the BCL-2 protein family controls Mitochondrial Outer Membrane Permeabilization (MOMP), but the dynamics of this regulation remains controversial. We employed chimeric proteins composed of exogenous BH3 domains inserted into a tBID backbone that can activate the pro-apoptotic effec...

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Hauptverfasser: Llambi, Fabien, Moldoveanu, Tudor, Tait, Stephen W.G., Bouchier-Hayes, Lisa, Temirov, Jamshid, McCormick, Laura L., Dillon, Christopher P., Green, Douglas R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3221787/
https://ncbi.nlm.nih.gov/pubmed/22036586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.10.001
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