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Nicastrin and related components of γ-secretase generate a peptide epitope facilitating immune recognition of intracellular mycobacteria, through MHC-II dependent priming of T cells
BCG, the anti- tuberculosis vaccine localizes within immature phagosomes of macrophages and dendritic cells (APCs) and avoids lysosomal degradation. BCG-derived antigenic peptides are thus inefficiently processed by APCs, and we investigated alternate mechanisms of antigen processing. Proteomics ide...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3221744/ https://ncbi.nlm.nih.gov/pubmed/22039303 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1100521 |
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