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Nicastrin and related components of γ-secretase generate a peptide epitope facilitating immune recognition of intracellular mycobacteria, through MHC-II dependent priming of T cells

BCG, the anti- tuberculosis vaccine localizes within immature phagosomes of macrophages and dendritic cells (APCs) and avoids lysosomal degradation. BCG-derived antigenic peptides are thus inefficiently processed by APCs, and we investigated alternate mechanisms of antigen processing. Proteomics ide...

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Detalhes bibliográficos
Main Authors: Singh, Christopher R., Bakhru, Pearl, Khan, Arshad, Li, Qing Bo, Jagannath, Chinnaswamy
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3221744/
https://ncbi.nlm.nih.gov/pubmed/22039303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1100521
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