Evaluation of an AAV2-Based Rapamycin-Regulated Glial Cell Line-Derived Neurotrophic Factor (GDNF) Expression Vector System

Effective regulation of transgene product in anatomically circumscribed brain tissue is dependent on the pharmacokinetics of the regulating agent, the kinetics of transcriptional activation and degradation of the transgene product. We evaluated rapamycin-regulated AAV2-GDNF expression in the rat bra...

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Autores principales: Hadaczek, Piotr, Beyer, Janine, Kells, Adrian, Narrow, Wade, Bowers, William, Federoff, Howard J., Forsayeth, John, Bankiewicz, Krystof S.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2011
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3221672/
https://ncbi.nlm.nih.gov/pubmed/22132130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027728
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