Scoparone potentiates transactivation of the bile salt export pump gene and this effect is enhanced by cytochrome P450 metabolism but abolished by a PKC inhibitor

BACKGROUND AND PURPOSE: Hyperbilirubinaemia and cholestasis are two major forms of liver abnormality. The Chinese herb Yin Chin has been used for thousands of years to treat liver dysfunctions. In mice, this herb and its principal ingredient scoparone were found to accelerate the clearance of biliru...

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Detalles Bibliográficos
Autores principales: Yang, Dongfang, Yang, Jian, Shi, Deshi, Deng, Ruitang, Yan, Bingfang
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Publishing Ltd 2011
Materias:
Research Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3221107/
https://ncbi.nlm.nih.gov/pubmed/21649640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01522.x
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